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Scientists identify molecular system that could help develop potential...

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.

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Green tea extract interferes with the formation of amyloid plaques in...

Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.

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Normal prion protein regulates iron metabolism

An iron imbalance caused by prion proteins collecting in the brain is a likely cause of cell death in Creutzfeldt-Jakob disease (CJD), researchers at Case Western Reserve University School of Medicine...

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Scientists identify molecular trigger for Alzheimer's disease

Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of...

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From trauma to tau: Researchers tie brain injury to toxic form of protein

University of Texas Medical Branch at Galveston researchers have uncovered what may be a key molecular mechanism behind the lasting damage done by traumatic brain injury.

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Interferon-beta aids balance and movement in mice with spinocerebellar ataxia 7

The group of genetic conditions known as spinocerebellar ataxias currently have no treatment or cure and are always fatal, in the case of affected children at an early age. Symptoms include a...

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Rat hippocampal neurons: An executor of neuroinflammation

Recent findings suggest that Toll-like receptor 4 expressed in the central nervous system, especially in glial cells, plays a vital role in neuroinflammation and neurodegenerative conditions....

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Cranial irradiation causes brain degeneration

(Medical Xpress)—Cranial irradiation saves the lives of brain cancer patients. It slows cancer progression and increases survival rates. Unfortunately, patients who undergo cranial irradiation often...

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Receptor may aid spread of Alzheimer's and Parkinson's in brain

(Medical Xpress)—Scientists at Washington University School of Medicine in St. Louis have found a way that corrupted, disease-causing proteins spread in the brain, potentially contributing to...

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Learning how the brain takes out its trash may help decode neurological diseases

Imagine that garbage haulers don't exist. Slowly, the trash accumulates in our offices, our homes, it clogs the streets and damages our cars, causes illness and renders normal life impossible.

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More diseases responsible for dementia than previously thought, research finds

A recent study by the Clinical Institute of Neurology at the MedUni Vienna has shown that neurodegenerative diseases other than Alzheimer's disease are more common among older people than previously...

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Newly identified antibodies effectively treat Alzheimer's-like disease in mice

Alzheimer's disease is characterized by the accumulation of particular toxic proteins in the brain that are believed to underlie the cognitive decline in patients. A new study conducted in mice...

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Drug reduces brain changes, motor deficits associated with Huntington's disease

A drug that acts like a growth-promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study...

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Scientists discover trigger for protective immune response to spinal cord...

Hot on the heels of discovering a protective form of immune response to spinal cord injury, researchers at the University of Virginia School of Medicine have pinpointed the biological trigger for that...

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Astrocytes in the neurodegerating brain

Researchers from Trinity College Dublin have discovered that specialised 'astrocytes' abandon their posts as protectors and repairers of the brain when primed by the neurodegeneration of cells around...

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Blood-based biomarkers may lead to earlier diagnosis of Parkinson's disease

Parkinson's disease (PD) is a progressive neurological condition. At present, it is usually diagnosed only when motor features are present. Hence, there is a need to develop objective and measurable...

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Parkinson's disease: Parkin protects from neuronal cell death

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

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Can your brain control how it loses control?

A new study may have unlocked understanding of a mysterious part of the brain—with implications for neurodegenerative conditions such as Alzheimer's. The results, published in Translational Vision...

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Zebrafish study offers insights into nerve cell repair mechanisms

Tropical fish may hold clues that could aid research into motor neuron disease and paralysis caused by spinal cord injury.

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Tracing a path toward neuronal cell death

A fruit fly model of a rare, neurodegenerative disease is helping researchers trace the series of steps that lead to neuronal cell death. Damage to astrocytes - star-shaped cells found in the brain and...

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Could a new class of fungicides play a role in autism, neurodegenerative...

Scientists at the UNC School of Medicine have found a class of commonly used fungicides that produce gene expression changes similar to those in people with autism and neurodegenerative conditions,...

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How prions kill neurons: New culture system shows early toxicity to dendritic...

Prion diseases are fatal and incurable neurodegenerative conditions of humans and animals. Yet, how prions kill nerve cells (or neurons) remains unclear. A study published on May 26, 2016 in PLOS...

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New ALS discovery: Scientists reverse protein clumping involved in...

In the quest to understand the driving forces behind neurodegenerative diseases, researchers in recent years have zeroed in on clumps of malfunctioning proteins thought to kill neurons in the brain and...

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Cell protein offers new hope in fighting the effects of aging

A protein found within the powerhouse of a cell could be the key to holding back the march of time, research by scientists at The University of Nottingham has shown.

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How protein fragments associated with Alzheimer's could trigger Parkinson's

Alzheimer's and Parkinson's diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two. Now...

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Protein build-up may trigger inflammation associated with Alzheimer's and...

A recent review article published online in The FASEB Journal points to the "trigger" for the inflammatory response, caused by the immune system, that precedes Alzheimer's disease and other...

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One step closer to finding out how wine may protect your neurons

Let it be no misunderstanding: heavy alcohol intake has severe harmful effects. But already for several years, researchers have been finding that moderate wine intake can be beneficial in delaying the...

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Phagocytes in the brain—good or bad?

The role of microglial cells in neurodegenerative disease is not fully understood. But new results from researchers in Munich and Basel suggest that stimulation of this arm of the immune system might...

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Songbird study shows how estrogen may stop infection-induced brain inflammation

The chemical best-known as a female reproductive hormone—estrogen—could help fight off neurodegenerative conditions and diseases in the future. Now, new research by American University neuroscience...

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Study reveals new mechanisms of cell death in neurodegenerative disorders

Researchers at King's College London have discovered new mechanisms of cell death, which may be involved in debilitating neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

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