Lithium profoundly prevents brain damage associated with Parkinson's disease
Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD) in a mouse model of the condition.
View ArticleObservations refute widely held view on causal mechanism in amyotrophic...
In science, refuting a hypothesis can be as significant as proving one, all the more so in research aimed at elucidating how diseases proceed with a view toward preventing, treating, or curing them....
View ArticlePatients to benefit from better advice on pain control
New UK guidance for doctors and other prescribers on the use of strong painkillers for patients with chronic or incurable disease has been welcomed by researchers at the University of Leeds.
View ArticleScientists discover gene which causes rare disease in babies
A rare disease which often first presents in newborn babies has been traced to a novel genetic defect, scientists at Queen Mary, University of London have found.
View ArticleResearchers design new substances that might help fight Alzheimer's and...
University of Granada researchers have tested melatonin analogues in rats that inhibit the enzyme nitric oxide synthase, which is involved in the development of the diseases referred above.
View ArticleTwo proteins offer a 'clearer' way to treat Huntington's disease
In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins...
View ArticleRejected drug may protect against toxic substance common to Alzheimer's and...
The second of two studies on latrepirdine, recently published in Molecular Psychiatry, demonstrates new potential for the compound in the treatment of Alzheimer's disease, Parkinson's disease, sleep...
View ArticleStudy reveal brain cells' weakest links
(Medical Xpress)—People with degenerative neurological conditions could benefit from research that shows why their brain cells stop communicating properly.
View ArticleStudy examines delayed, misdiagnosis of sporadic Jakob-Creutzfeldt disease
A medical record review study of 97 patients with the fatal, degenerative brain disorder sporadic Jakob-Creutzfeldt disease (sCJD) suggests that a correct diagnosis of the disease was often delayed by...
View ArticleDrug shows promise in animal model of Alzheimer's and Parkinson's with dementia
New research presented in October at the 6th Neurodegenerative Conditions Research and Development Conference in San Francisco demonstrates the role of the investigational compound IRX4204 in...
View ArticleScientists block toxic protein that plays key role in Lou Gehrig's disease
October 28, 2012— Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells....
View ArticleNeurons made from stem cells drive brain activity after transplantation in...
(Medical Xpress)—Researchers and patients look forward to the day when stem cells might be used to replace dying brain cells in Alzheimer's disease and other neurodegenerative conditions. Scientists...
View ArticleNew understanding can lead to srategies for dealing with neurodegenerative...
A new understanding of what takes place on the cellular level during the development of neurodegenerative diseases, such as Parkinson's, Alzheimer's, ALS and Huntington's diseases, offers promise...
View ArticleScientists identify molecular system that could help develop potential...
Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.
View ArticleGreen tea extract interferes with the formation of amyloid plaques in...
Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.
View ArticleNormal prion protein regulates iron metabolism
An iron imbalance caused by prion proteins collecting in the brain is a likely cause of cell death in Creutzfeldt-Jakob disease (CJD), researchers at Case Western Reserve University School of Medicine...
View ArticleScientists identify molecular trigger for Alzheimer's disease
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of...
View ArticleFrom trauma to tau: Researchers tie brain injury to toxic form of protein
University of Texas Medical Branch at Galveston researchers have uncovered what may be a key molecular mechanism behind the lasting damage done by traumatic brain injury.
View ArticleInterferon-beta aids balance and movement in mice with spinocerebellar ataxia 7
The group of genetic conditions known as spinocerebellar ataxias currently have no treatment or cure and are always fatal, in the case of affected children at an early age. Symptoms include a...
View ArticleRat hippocampal neurons: An executor of neuroinflammation
Recent findings suggest that Toll-like receptor 4 expressed in the central nervous system, especially in glial cells, plays a vital role in neuroinflammation and neurodegenerative conditions....
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